Abstract: Climate warming is accelerating the degradation of permafrost, and the interaciton between permafrost and vegetation regulates carbon-nutrient cycle, surface albedo and transpiration, which deeply impacts regional carbon balance, biodiversity and hydrological processes. However, the systematic analysis of the interaction between permafrost and vegetation is insufficient, and the scientific nature of ecological restoration strategy and the trade-off between the advantages and disadvantages of permafrost degradation lack sufficient theoretical support. In this paper, the impact of permafrost degradation on vegetation characteristics, function interactions between permafrost degradation and vegetation, and human activities were reviewed. The literature review indicated that permafrost degradation changed soil hydrothermal conditions and carbon release, leading to the decline of alpine ecosystem stability, but its critical threshold and vegetation response mechanism were spatio-temporal heterogeneous. Human activities had accelerated the degradation of permafrost, and zonal management was needed to balance the relationship between permafrost and economic development. Multidisciplinary and intelligent algorithms were combined to build a technical system. In future development, it is necessary to quantify the critical threshold of permafrost degradation when the vegetation just started succession, and develop a permafrost-vegetation dynamic early warning system based on artificial intelligence, and improve the simulation capability of existing models and solve the problem of insufficient simulation capability of sudden thermal karst disasters, and establish a cross-scale monitoring platform to make up for the technical gap of long-term effect assessment of vegetation restoration technology, and formulate classification control standards for permafrost degradation risk, and construct a collaborative framework of ecological protection and community development in permafrost regions to promote scientific decision-making on climate change adaptation policies. It is suggested that the carbon sink potential of permafrost should be incorporated into the national carbon neutrality strategy, and the ecological compensation mechanism should be promoted to provide a paradigm for the sustainable development of global alpine regions. In this paper, the mechanism of permafrost-vegetation mutual feedback between Qinghai-Tibet Plateau and Pan-Arctic region was systematically integragted, and the management framework of interdisciplinary data fusion was proposed, which filled the theoretical gap of alpine ecosystem restoration strategy.